Principal AI Engineer

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care. What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you. The Principal AI Engineer provides the highest level of individual-contributor technical leadership for the company's AI platform, operating one level above the Lead AI Engineer role. This person sets the multi-year architecture strategy for agentic and LLM-powered systems — spanning model strategy, retrieval-augmented generation (RAG), tool/connector ecosystems, and evaluation/governance tooling — across every team that builds on the AI platform, not just one. In a highly regulated healthcare environment, the Principal AI Engineer resolves the hardest, most ambiguous technical problems facing the platform, is a primary technical voice with executive leadership on AI strategy and risk, and shapes how the entire engineering organization adopts AI safely and effectively. Success is measured by the durability and adoption of the technical strategy this role sets across multiple